Researching and understanding the role of tau protein in neurodegenerative diseases.

Pathological aggregation of the microtubule-associated protein tau and the preponderance of neurofibrillary tangles (NFT) or other inclusions containing tau are the defining histopathological features of Alzheimer’s disease and more than 20 other neurodegenerative tauopathies. Therefore, the study of the physiological and pathological function of tau is key to understanding and treating these neurodegenerative diseases. Hence, the main focus of the Lasagna-Reeves Lab is to comprehensively elucidate the role that tau physiology plays in neurodegenerative tauopathies.